蜂膠的消炎鎮痛作用

蜂(feng)膠(jiao)是(shi)很好的消炎(yan)鎮痛劑，用(yong)(yong)(yong)(yong)蜂(feng)膠(jiao)提取液治療大白鼠(shu)關節炎(yan)的實驗(yan)(yan)證(zheng)明(ming)蜂(feng)膠(jiao)有抗炎(yan)作(zuo)(zuo)用(yong)(yong)(yong)(yong)；用(yong)(yong)(yong)(yong)甲(jia)醇誘(you)導小鼠(shu)關節炎(yan)和水腫(zhong)，然(ran)(ran)后(hou)(hou)(hou)(hou)用(yong)(yong)(yong)(yong)蜂(feng)膠(jiao)進(jin)(jin)行試驗(yan)(yan)，證(zheng)明(ming)蜂(feng)膠(jiao)對(dui)這兩種炎(yan)癥均有抗炎(yan)效果，用(yong)(yong)(yong)(yong)蜂(feng)膠(jiao)和阿(a)司匹林(0. 2g/kg)對(dui)照，給大鼠(shu)口服受藥后(hou)(hou)(hou)(hou)1小時(shi)，將其后(hou)(hou)(hou)(hou)肢進(jin)(jin)行人工誘(you)發炎(yan)癥性水腫(zhong)，然(ran)(ran)后(hou)(hou)(hou)(hou)每小時(shi)測定其炎(yan)癥腫(zhong)脹(zhang)的程度，試驗(yan)(yan)證(zheng)明(ming)，蜂(feng)膠(jiao)和阿(a)司匹林對(dui)炎(yan)癥腫(zhong)脹(zhang)都有抑制作(zuo)(zuo)用(yong)(yong)(yong)(yong)，而且它們的抗炎(yan)作(zuo)(zuo)用(yong)(yong)(yong)(yong)十分相(xiang)似。用(yong)(yong)(yong)(yong)二(er)甲(jia)苯涂抹小鼠(shu)耳(er)部使鼠(shu)耳(er)腫(zhong)脹(zhang)，試驗(yan)(yan)證(zheng)明(ming)，蜂(feng)膠(jiao)抗炎(yan)作(zuo)(zuo)用(yong)(yong)(yong)(yong)比“消炎(yan)痛”強。

蜂(feng)(feng)膠(jiao)有鎮痛(tong)作(zuo)用(yong)(yong)。沈勝利等(1986)選擇雄(xiong)性小(xiao)鼠采(cai)用(yong)(yong)電(dian)擊法，試驗結果證(zheng)明，蜂(feng)(feng)膠(jiao)對電(dian)擊小(xiao)鼠尾(wei)根部具有鎮痛(tong)作(zuo)用(yong)(yong)，并能維持一(yi)定(ding)時間。峰下哲等(1992)采(cai)用(yong)(yong)給小(xiao)鼠腹腔注射0.7%乙酸，引起扭曲反應作(zuo)為指標，證(zheng)明了蜂(feng)(feng)膠(jiao)經口飼(si)喂能達到與消(xiao)炎痛(tong)同等或更強的鎮痛(tong)效應。

蜂(feng)膠(jiao)(jiao)有很強的(de)抗潰(kui)(kui)(kui)(kui)瘍(yang)(yang)(yang)(yang)(yang)作用。用五氧(yang)化二砷和(he)咖啡因給(gei)大鼠(shu)(shu)造成實(shi)驗(yan)性(xing)胃(wei)潰(kui)(kui)(kui)(kui)瘍(yang)(yang)(yang)(yang)(yang)，試(shi)驗(yan)證明(ming)(ming)，給(gei)蜂(feng)膠(jiao)(jiao)浸液(ye)和(he)甲(jia)基尿嘧(mi)啶的(de)治(zhi)療(liao)組(zu)(zu)，其(qi)大白(bai)(bai)鼠(shu)(shu)潰(kui)(kui)(kui)(kui)瘍(yang)(yang)(yang)(yang)(yang)愈(yu)(yu)合(he)(he)平均面積(ji)相似，均比對(dui)照(zhao)組(zu)(zu)(給(gei)水)的(de)潰(kui)(kui)(kui)(kui)瘍(yang)(yang)(yang)(yang)(yang)平均愈(yu)(yu)合(he)(he)而(er)積(ji)小得多(duo)，表現為(wei)中毒(du)癥狀(zhuang)輕，體重增加，而(er)對(dui)照(zhao)組(zu)(zu)卻(que)呈(cheng)現亞急性(xing)砷中毒(du);用粒狀(zhuang)氫氧(yang)化鈉將(jiang)金(jin)黃地鼠(shu)(shu)背(bei)前(qian)部致為(wei)實(shi)驗(yan)性(xing)潰(kui)(kui)(kui)(kui)瘍(yang)(yang)(yang)(yang)(yang)，用蜂(feng)膠(jiao)(jiao)酊(ding)涂抹潰(kui)(kui)(kui)(kui)瘍(yang)(yang)(yang)(yang)(yang)處(chu)，與不涂藥處(chu)對(dui)照(zhao)，其(qi)結果證明(ming)(ming)，蜂(feng)膠(jiao)(jiao)酊(ding)能促進潰(kui)(kui)(kui)(kui)瘍(yang)(yang)(yang)(yang)(yang)愈(yu)(yu)合(he)(he)，縮(suo)短病程(cheng)1/2一1/3。從(cong)病理學(xue)鏡檢觀察，蜂(feng)膠(jiao)(jiao)確(que)有消炎，促進組(zu)(zu)織修(xiu)復的(de)功效。用濃乙酸對(dui)雄性(xing)大白(bai)(bai)鼠(shu)(shu)胃(wei)壁造成潰(kui)(kui)(kui)(kui)瘍(yang)(yang)(yang)(yang)(yang)，實(shi)驗(yan)證明(ming)(ming)，蜂(feng)膠(jiao)(jiao)有愈(yu)(yu)合(he)(he)作用，不僅潰(kui)(kui)(kui)(kui)瘍(yang)(yang)(yang)(yang)(yang)愈(yu)(yu)合(he)(he)率(lv)明(ming)(ming)顯高于對(dui)照(zhao)組(zu)(zu)，而(er)且潰(kui)(kui)(kui)(kui)瘍(yang)(yang)(yang)(yang)(yang)面積(ji)縮(suo)小和(he)病理組(zu)(zu)織學(xue)改變亦(yi)有明(ming)(ming)顯差(cha)別。